| Number | Name | Air date |
|---|---|---|
| 1 | Elliott Gould/Kid Creole and the Coconuts | 11/15/1980 |
| 2 | Malcolm McDowell/Captain Beefheart and the Magic Band | 11/22/1980 |
| 3 | Ellen Burstyn/Aretha Franklin | 12/06/1980 |
| 4 | Jamie Lee Curtis/James Brown | 12/13/1980 |
| 5 | David Carradine/Linda Ronstadt/Cast of 'The Pirates of Penzance' | 12/20/1980 |
| 6 | Ray Sharkey/Jack Bruce and Friends | 01/10/1981 |
| 7 | Karen Black/Cheap Trick, Stanley Clarke Trio | 01/17/1981 |
| 8 | Robert Hays/14 Karat Soul, Joe 'King' Carrasco & The Crowns | 01/24/1981 |
| 9 | Sally Kellerman/Jimmy Cliff | 02/07/1981 |
| 10 | Deborah Harry/Funky 4 + 1 More | 02/14/1981 |
| 11 | Charlene Tilton/Todd Rundgren, Prince | 02/21/1981 |
| 12 | Bill Murray/Delbert McClinton | 03/07/1981 |
| 13 | Chevy Chase/Jr. Walker and the All Stars | 04/11/1981 |
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